Water → HCID 14209239, Verbindung

HRID 1252402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1252402
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH2:13]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:4][CH2:3][CH:2]([OH:13])[CH3:11])=[CH:9][CH:8]=[CH:7][CH:6]=2

Komponenten

3

Edukt 2

HCID 962WaterHCID 6183063-Bromo-4-chloroquinoline

Produkt 1

HCID 14209239HCID 14209239, Verbindung

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

A mixture of 3 g of 3-bromo-4-chloro-quinoline and 10 g of aminopropanol-2 was heated to 150° C. for 20 minutes. The mixture was cooled and poured into 120 ml of water and the product was extracted with 100 ml of ether. The ether layer was dried over sodium sulfate, the solvent removed by evaporation and the residue recrystallized from ether/hexane. The yield was 2.6 g, mp 82°-83° C.

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. extractionthe product was extracted with 100 ml of ether
  3. dry with materialThe ether layer was dried over sodium sulfate
  4. customthe solvent removed by evaporation
  5. customthe residue recrystallized from ether/hexane

Quellen und Nachweise

ORD-Eintrag
ord-ccca9300df774a6ba48d9a6574112126
Quelldatensatz
uspto-grants-1988_05
Patentnummer
US04743601

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