Hydrogen Bromide → HCID 67207447, Verbindung

HRID 1253539Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1253539
[Br:1][C:2]1[CH:3]=[C:4]([O:11]C)[C:5]2[N:6]([N:8]=[CH:9][CH:10]=2)[CH:7]=1.Br.[OH-].[Na+]>O.C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([OH:11])[C:5]2[N:6]([N:8]=[CH:9][CH:10]=2)[CH:7]=1

Komponenten

6

Edukt 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 446228256-Bromo-4-methoxypyrazolo[1,5-a]pyridine

Produkt 1

HCID 67207447HCID 67207447, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

6-bromo-4-methoxypyrazolo[1,5-a]pyridine (1.50 g, 6.61 mmol) was suspended in HBr (15 ml, 133 mmol). The reaction mixture was heated in the Biotage Initiator Series microwave for 80 minutes at 150° C. The reaction mixture was added dropwise via pipette to a mixture of NaOH (5.29 g, 132 mmol) in 50 mL of water and ice. The mixture was diluted in ethyl acetate, washed with saturated aqueous sodium bicarbonate and brine then dried over sodium sulfate, filtered and concentrated to give 6-bromopyrazolo[1,5-a]pyridin-4-ol.

Aufarbeitung

  1. washwashed with saturated aqueous sodium bicarbonate and brine
  2. dry with materialthen dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-f7583cc29d5647949bc680136988c357
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455477B2

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