HCID 67314789, Verbindung → HCID 67314740, Verbindung
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[C:12]1[C:20]2[C:15](=[N:16][C:17]([CH:21]=[CH:22][O:23][CH3:24])=[CH:18][CH:19]=2)[CH2:14][O:13]1>CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[C:12]1[C:20]2[C:15](=[N:16][C:17]([CH2:21][CH2:22][O:23][CH3:24])=[CH:18][CH:19]=2)[CH2:14][O:13]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 5-fluoro-3-[2-(2-methoxy-vinyl)-7H-furo[3,4-b]pyridin-5-ylidene]-1,3-dihydro-indol-2-one (27 mg, 0.08 mmol) in 10 mL MeOH is treated with palladium (10% on activated carbon, 27 mg) under an argon atmosphere. The resulting mixture is subject to hydrogenation at a pressure of 35 psi for 12 h. The reaction mixture is filtered, concentrated, and the residue is chromatographed (silica gel, MeOH-Chloroform). The product containing fractions are concentrated to give the title compound as yellow solid (5 mg, 18%).