Sodium Hydroxide → (R)-2-((Benzyloxy)methyl)morpholine

Temperatur

40 °C

To a stirred mixture of (R)-2-(benzyloxymethyl)oxirane (10.0 g, 60.9 mmol) and NaOH (19.49 g, 487.2 mmol) in H2O (46 mL) and MeOH (18 mL), there was added 2-aminoethyl hydrogen sulfate (36.8 g, 255.8 mmol) in portions. After addition the reaction mixture was stirred at 40° C. for 2 h. After cooling, the mixture was treated with NaOH (15.0 g, 375.0 mmol) then toluene (70 mL) and stirred at 65° C. overnight. The mixture was cooled, diluted with toluene (27 mL) and H2O (92 mL). The toluene layer was separated and the aqueous layer was extracted with CH2Cl2 (2×50 mL). The combined organic layers were concentrated to give crude (R)-2-(benzyloxymethyl)morpholine (˜14 g), which was used without purification. MS m/z 208 (M+H+).

1. additionAfter addition the reaction mixture
2. temperatureAfter cooling
3. temperatureThe mixture was cooled
4. customThe toluene layer was separated
5. extractionthe aqueous layer was extracted with CH2Cl2 (2×50 mL)
6. concentrationThe combined organic layers were concentrated

ORD-Eintrag

ord-3e36eb5fee4e45fa825131b340e7f5f8

Quelldatensatz

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08455521B2