Lithium hydroxide, monohydrate → (R)-2-(1-allyl-2-(1-phenylethylcarbamoyl)hydrazinyl)acetic acid
Reaktionsgleichung
[CH2:1]([N:4]([CH2:17][C:18]([O:20]CC)=[O:19])[NH:5][C:6](=[O:16])[NH:7][C@@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:9])[CH:2]=[CH2:3].O.[OH-].[Li+]>>[CH2:1]([N:4]([CH2:17][C:18]([OH:20])=[O:19])[NH:5][C:6](=[O:16])[NH:7][C@@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:9])[CH:2]=[CH2:3]Komponenten
3
Versuchsvorschrift
According to the procedure described in the synthesis method of Compound VI-2 with the modification that the reaction was carried out for 2 hours, (R)-ethyl 2-(1-allyl-2-(1-phenylethylcarbamoyl)hydrazinyl)acetate (Compound V-3) 229 mg (0.75 mmol) was reacted with lithium hydroxide monohydrate 38 mg (0.9 mmol) to obtain the title compound 202 mg (97%).
Aufarbeitung
- customdescribed in the synthesis method of Compound VI-2 with the modification that the reaction