Triethylamine → HCID 136356802, Verbindung

Temperatur

80 °C

To a solution of the title compound from Example 16 Step A (0.500 grams, 2.42 mmol) in ethanol (20 mL) was added hydrazine hydrate (3.25 mL, 35% v/v, 36.3 mmol). The reaction flask was equipped with a reflux condenser, and the reaction mixture was stirred at 80° C. After 12 h, the mixture was allowed to cool to room temperature, whereupon a yellow solid precipitated. The solid was triturated with hexanes, filtered, washed with water, and dried in vacuo: LCMS m/z 203.2 [M+H]+. To a solution of the crude pyrazinyl hydrazine in acetonitrile (10 mL) were added triethylamine (0.675 mL, 4.84 mmol) and ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate (0.872 g, 3.63 mmol). After 40 min at ambient temperature, the reaction mixture was placed in a 60° C. bath and was stirred for 30 min, at which point the reaction mixture was allowed to cool to ambient temperature, then was concentrated in vacuo. Purification by flash chromatography on silica gel (0 to 60% EtOAc in hexanes, then 60 to 100% EtOAc in hexanes) provided the title compound: LCMS m/z 379.1 [M+H]+; 1H NMR (500 MHz, CDCl3) δ 10.98 (s, 1H), 9.35 (s, 1H), 8.85 (s, 1H), 8.23 (s, 1H), 7.93 (dd, J=8.0, 1.5 Hz, 1H), 7.43 (t, J=8.0 Hz, 1H), 7.07 (d, J=8.5 Hz, 1H), 7.04 (t, J=8.0 Hz, 1H).

1. customThe reaction flask was equipped with a reflux condenser
2. temperatureto cool to room temperature, whereupon a yellow solid
3. customprecipitated
4. customThe solid was triturated with hexanes
5. filtrationfiltered
6. washwashed with water
7. customdried in vacuo
8. waitAfter 40 min at ambient temperature
9. customwas placed in a 60° C.
10. stirringwas stirred for 30 min, at which
11. temperatureto cool to ambient temperature
12. concentrationwas concentrated in vacuo
13. customPurification by flash chromatography on silica gel (0 to 60% EtOAc in hexanes

ORD-Eintrag

ord-ba8f193f0059420bbbb5d568866b5d47

Quelldatensatz

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08455638B2