Hydrochloric Acid → 3-(2-(tert-Butyldimethylsilyloxy)ethylthio)benzoic acid

(2-Bromoethoxy)(tert-butyl)dimethylsilane (1.48 mL) was added dropwise to a suspension of 3-mercaptobenzoic acid (1.07 g) and potassium carbonate (1.91 g) in DMF (15 mL). The resulting suspension was stirred for 2 h. The reaction was carefully acidified by dropwise addition of aqueous HCl (2M, 10 mL) and poured into water (100 mL). The resulting aqueous was extracted with ethyl acetate (3×100 mL). The combined organics were washed with brine (50 mL), dried over sodium sulphate, filtered and evaporated to give the subtitled compound as a clear oil. Yield 2.8 g.

1. extractionThe resulting aqueous was extracted with ethyl acetate (3×100 mL)
2. washThe combined organics were washed with brine (50 mL)
3. dry with materialdried over sodium sulphate
4. filtrationfiltered
5. customevaporated

ORD-Eintrag

ord-c24c76eeafc549198bdd16eb8b32df04

Quelldatensatz

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08455483B2