Ethanol → 6-Bromopyrazolo[1,5-a]pyrimidine

HRID 1255861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1255861
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[Br:7]/[C:8](=[CH:11]\N(C)C)/[CH:9]=O.C(O)C>C(O)(=O)C>[Br:7][C:8]1[CH:9]=[N:1][C:2]2[N:3]([N:4]=[CH:5][CH:6]=2)[CH:11]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 215914792-Bromo-3-(dimethylamino)acroleinHCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 222367016-Bromopyrazolo[1,5-a]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

3-Aminopyrazole (0.75 g, 9.04 mmol) was mixed with (2Z)-2-bromo-3-(dimethylamino)acrylaldehyde obtained at the previous step (1.85 g, 10.4 mmol). Absolute ethanol (20 mL) and glacial acetic acid (2 mL) were added. The reaction mixture was stirred under reflux for 16 h and evaporated to dryness. The residue was washed on a filter with cold ethanol/hexane mixture (3:1) and dried in a vacuum oven at 30° C. to give 6-bromopyrazolo[1,5-a]pyrimidine.

Aufarbeitung

  1. customobtained at the previous step (1.85 g, 10.4 mmol)
  2. temperatureunder reflux for 16 h
  3. customevaporated to dryness
  4. washThe residue was washed on
  5. filtrationa filter with cold ethanol/hexane mixture (3:1)
  6. customdried in a vacuum oven at 30° C.

Quellen und Nachweise

ORD-Eintrag
ord-8193ef84867742bfaacde2bfec964037
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461162B2

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