Hydrazine hydrate (1:1) → N4-Phenylquinazoline-4,6-diamine

HRID 1255976

Reaktionsgleichung

Reaktionsgleichung von HRID 1255976
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][N:8]=[C:7]2[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([O-])=O.O.NN>C(O)C.O.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][N:8]=[C:7]2[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

5

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 53281896-Nitro-N-phenylquinazolin-4-amine

Produkt 1

HCID 5328187N4-Phenylquinazoline-4,6-diamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

A solution of a 6-nitro-4-(phenylamino)quinazoline substituted by a polyalkylene glycol derivative terminating with a fifth reactive group, prepared as described hereinabove, in ethanol/water is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel (Ra—Ni). The reaction mixture is filtered and evaporated, to give the corresponding 6-amino-4-(phenylamino)quinazoline substituted by a polyalkylene glycol moiety terminating with a reactive group.

Aufarbeitung

  1. customterminating with a fifth reactive group
  2. customprepared
  3. filtrationThe reaction mixture is filtered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-cb036731962c42c7a75e6196a3c6d492
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461166B2

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