Oxalyl chloride → Methyl 4-(2-chloro-2-oxoethyl)benzoate

HRID 1257474Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1257474
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)=[O:4].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[Cl:18][C:12](=[O:14])[CH2:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 107978792-(4-(Methoxycarbonyl)phenyl)acetic acid

Produkt 1

HCID 19746402Methyl 4-(2-chloro-2-oxoethyl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of the compound (3.0 g) obtained in Example 206a in dichloromethane (50 mL) was cooled in an ice bath, and oxalyl chloride (3.93 g) and N,N-dimethylformamide (2 drops) were added. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure to give the title compound.

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f6db7af0968d4d169df79cf7eee4e942
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461348B2

Notizen zur Reaktion

Wird geladen…