Sodium Dithionite → 5,6-Diamino-3-propylpyrimidine-2,4(1H,3H)-dione

HRID 1258026Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258026
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[C:3]=1[N:13]=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>N>[NH2:13][C:3]1[C:4](=[O:12])[N:5]([CH2:9][CH2:10][CH3:11])[C:6](=[O:8])[NH:7][C:2]=1[NH2:1]

Komponenten

4

Edukt 2

HCID 24489Sodium DithioniteHCID 144253236-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 109542025,6-Diamino-3-propylpyrimidine-2,4(1H,3H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 222AmmoniaLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

To a solution of 6-amino-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione (5.4 g, 27 mmol) in 12.5% aqueous ammonia (135 ml) at 70° C. was added sodium dithionite (Na2S2O4, 9.45 g, 54 mmol) in portions over 15 minutes, and the mixture was stirred for 20 minutes. The solution was concentrated under reduced pressure, cooled to 5° C., the precipitate filtered off, and washed with cold water, to provide 5,6-diamino-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (12).

Aufarbeitung

  1. concentrationThe solution was concentrated under reduced pressure
  2. filtrationthe precipitate filtered off
  3. washwashed with cold water

Quellen und Nachweise

ORD-Eintrag
ord-f42deebcd1ac4ea188d977a3c035fe90
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466129B2

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