Sodium Dithionite → 5,6-Diamino-1-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Temperatur

5 °C

To a solution of 6-amino-1-ethyl-5-nitroso-1,3-dihydropyrimidine-2,4-dione (3.9 g, 21.2 mmol) in 14.5% aqueous ammonia (50 ml) at 50° C. was added sodium dithionite (Na2S2O4, 7.37 g, 42.4 mmol) in portions over 15 minutes, and the mixture was stirred for 20 minutes. The solution was concentrated under reduced pressure to a volume of 30 ml, cooled to 5° C., the precipitate filtered off, and washed with cold water, to provide 5,6-diamino-1-ethyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (15).

1. concentrationThe solution was concentrated under reduced pressure to a volume of 30 ml
2. filtrationthe precipitate filtered off
3. washwashed with cold water

ORD-Eintrag

ord-541aa4af663f44629fd84555ec6bbb02

Quelldatensatz

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08466129B2