Hydrochloric Acid → HCID 72280550, Verbindung

HRID 1258444Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258444
Cl.[N:2]1([CH2:8][CH:9]=[CH:10][C:11]([OH:13])=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C(Cl)(=O)C([Cl:17])=O>ClCCl.CN(C)C=O>[N:2]1([CH2:8][CH:9]=[CH:10][C:11]([Cl:17])=[O:13])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 65578Oxalyl chlorideHCID 541093814-(1-Piperidinyl)-2-butenoic acid

Produkt 1

HCID 72280550HCID 72280550, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The HCl salt of 4-Piperidin-1-yl-but-2-enoic acid (250 mg, 1.48 mmol) was dissolved in dichloromethane (15 mL). Dimethylformamide (3 drops) was added. Oxalyl chloride (155 μL, 1.77 mmol) was added slowly and the reaction was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure and the residue was used as is.

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1bfe9cf3067b4ac291a15040699bd326
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466165B2

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