Methylamine → 4,5-Dichloro-n-methyl-2-nitroaniline

HRID 1258626

Reaktionsgleichung

Reaktionsgleichung von HRID 1258626
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5](F)=[CH:4][C:3]=1[Cl:12].[CH3:13][NH2:14]>CN(C=O)C>[Cl:1][C:2]1[C:3]([Cl:12])=[CH:4][C:5]([NH:14][CH3:13])=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 5339511,2-Dichloro-4-fluoro-5-nitrobenzene

Produkt 1

HCID 2893174,5-Dichloro-n-methyl-2-nitroaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1,2-Dichloro-4-fluoro-5-nitrobenzene (5.00 g, 23.8 mmol) in DMF (5.0 mL) was added to methylamine (10% in toluene, 80.0 g, 258 mmol) and stirred at rt overnight. The reaction mixture was filtered through a pad of ALOX B, washed with DMF/MeOH and concentrated to give the sub-title compound.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a pad of ALOX B
  2. washwashed with DMF/MeOH
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d61c36bcae2d495787174dc822b42dd2
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466186B2

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