Acetic Acid → 3-Amino-2,4-dichlorobenzoic acid

HRID 1258646Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258646
C([NH:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=O)C.C(O)(=O)C>Cl>[NH2:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 198331103-Acetamido-2,4-dichlorobenzoic acid

Produkt 1

HCID 152782343-Amino-2,4-dichlorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

3-Acetylamino-2,4-dichloro-benzoic acid (21.0 g, 84.6 mmol) was stirred in 6 M aq. HCl-solution (120 mL) and acetic acid (250 mL) at reflux for 24 h. The reaction mixture was cooled, concentrated, diluted with water and concentrated again. The residue was diluted with water, stirred under cooling and filtered. The filtercake was washed and dried to give the sub-title compound.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. additiondiluted with water
  4. concentrationconcentrated again
  5. additionThe residue was diluted with water
  6. temperatureunder cooling
  7. filtrationfiltered
  8. washThe filtercake was washed
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b48597ec34394e1e8283ebe92fde53a7
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466186B2

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