Diisopropylethylamine → 3-fluoro-N-(4-methoxybutyl)-2-nitroaniline

HRID 1259951Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1259951
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N+:9]([O-:11])=[O:10].C(N(C(C)C)CC)(C)C.Cl.[CH3:22][O:23][CH2:24][CH2:25][CH2:26][CH2:27][NH2:28]>C(#N)C>[F:8][C:4]1[C:3]([N+:9]([O-:11])=[O:10])=[C:2]([CH:7]=[CH:6][CH:5]=1)[NH:28][CH2:27][CH2:26][CH2:25][CH2:24][O:23][CH3:22]

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 879221,3-Difluoro-2-nitrobenzeneHCID 457923494-Methoxybutan-1-amine hydrochloride

Produkt 1

HCID 583554133-fluoro-N-(4-methoxybutyl)-2-nitroanilineAusbeute 66,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

To a solution of 1,3-difluoro-2-nitrobenzene (3.00 g) and diisopropylethylamine (7 μl) in acetonitrile (30 ml) was added a solution of 4-methoxybutan-1-amine hydrochloride (2.51 g) in acetonitrile (10 ml), and the mixture was stirred at room temperature for 90 hr. The reaction mixture was concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography, and a fraction eluted with ethyl acetate-hexane (2:98-25:75) was concentrated under reduced pressure to give the object product (2.90 g).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washa fraction eluted with ethyl acetate-hexane (2:98-25:75)
  3. concentrationwas concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cc0689c478bf4f628aff55a3cdde54da
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466282B2

Notizen zur Reaktion

Wird geladen…