Dimethylsulphamoyl chloride → HCID 178486183, Verbindung
Reaktionsgleichung
Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[CH3:28][N:29]([CH3:34])[S:30](Cl)(=[O:32])=[O:31]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][S:30]([N:29]([CH3:34])[CH3:28])(=[O:32])=[O:31])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1Komponenten
3
Versuchsvorschrift
The title compound, white solid (28 mg, 26%), MS (ISP) m/z=438.3 [(M+H)+], mp 128° C., was prepared in accordance with the general method of example 26 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (110 mg, 0.25 mmol) and dimethylsulfamoyl chloride.
Quellen und Nachweise
- ORD-Eintrag
- ord-dfe3ad9492ec4cba98dae5851d2ca33f
- Quelldatensatz
- uspto-grants-2013_06