Tert-butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate → 4-(Trifluoromethylphenyl)-piperidin-4-ol

HRID 1261653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1261653
[OH:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:21]([F:24])([F:23])[F:22])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1>Cl.CCOCC>[F:24][C:21]([F:22])([F:23])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:2]1([OH:1])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Komponenten

4

Edukt 1

HCID 49760255Tert-butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate

Produkt 1

HCID 226370654-(Trifluoromethylphenyl)-piperidin-4-olAusbeute 69,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

tert-Butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate (0.40 g, 1.0 mmol) was dissolved in a 2.0 M solution of HCl in ether (5 mL). After being stirred at room temperature overnight, the solution was diluted with ether. The white solid was filtered and washed with ether to give 170 mg of pure product. MS calculated for C12H14F3NO: (M+H) 246; found 246.1.

Aufarbeitung

  1. filtrationThe white solid was filtered
  2. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-1b4918ba3690449886c1af63127a8666
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470827B2

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