1-Methoxy-2-propanol → HCID 66711690, Verbindung
Reaktionsgleichung
CS([C:4]1[N:9]=[CH:8][C:7]2=[CH:10][CH:11]=[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH3:20])[N:6]2[N:5]=1)=O.C(N(CC)C(C)C)(C)C.[F:30][C:31]1[CH:36]=[C:35]([N:37]2[CH2:42][CH2:41][O:40][CH2:39][CH2:38]2)[CH:34]=[CH:33][C:32]=1[NH2:43].COCC(O)C>>[F:30][C:31]1[CH:36]=[C:35]([N:37]2[CH2:38][CH2:39][O:40][CH2:41][CH2:42]2)[CH:34]=[CH:33][C:32]=1[NH:43][C:4]1[N:9]=[CH:8][C:7]2=[CH:10][CH:11]=[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH3:20])[N:6]2[N:5]=1Komponenten
Versuchsvorschrift
2-Methanesulfinyl-7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (125.0 mg, 0.0004350 mol), N,N-Diisopropylethylamine (0.250 mL, 0.00144 mol) and 2-Fluoro-4-morpholin-4-yl-phenylamine (0.171 g, 0.000870 mol) were dissolved in 1-Methoxy-2-propanol (0.500 mL, 0.00512 mol) and the reaction was irradiated at 300 watts, 180° C. for 40 minutes or until HPLC showed consumption of starting material. The reaction mixture was then reduced en vacuo and the product was isolated and purified by Gilson prep HPLC to afford 36.52 mg of (2-Fluoro-4-morpholin-4-yl-phenyl)-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine as a lyophilized powder. (M+H)=420.1. 1H NMR (400 MHz, DMSO, d6) δ 8.90 (s, 1H), 8.48 (s, 1H), 7.84 (d, 1H, J=7.56 Hz), 7.56 (t, 1H, J=9.00 Hz), 7.38 (m, 1H), 7.14 (m, 1H), 7.01 (m, 2H), 6.88 (m, 2H), 6.67 (m, 1H), 3.78 (s, 3H), 3.74 (m, 4H), 3.09 (m, 4H).
Aufarbeitung
- customthe reaction was irradiated at 300 watts, 180° C. for 40 minutes or until HPLC
- customconsumption of starting material
- customthe product was isolated
- custompurified by Gilson prep HPLC
Quellen und Nachweise
- ORD-Eintrag
- ord-a9708418c4354ad18c253b865f2aac58
- Quelldatensatz
- uspto-grants-2013_06
- Patentnummer
- US08471005B2
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