Dimethylformamide → 2,6-dioxo-N-(carboxymethyl)morpholine

HRID 1262804

Reaktionsgleichung

Reaktionsgleichung von HRID 1262804
CN(C)C=O.C(OC(=O)C)(=O)C.[N:13]([CH2:22][C:23]([OH:25])=[O:24])([CH2:18][C:19]([OH:21])=O)[CH2:14][C:15]([OH:17])=[O:16]>N1C=CC=CC=1>[O:24]=[C:23]1[O:25][C:19](=[O:21])[CH2:18][N:13]([CH2:14][C:15]([OH:17])=[O:16])[CH2:22]1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 8758Nitrilotriacetic Acid

Produkt 1

HCID 1695312,6-dioxo-N-(carboxymethyl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A round bottom flask is charged with dimethylformamide 72 g, acetic anhydride 25 g, pyridine 2 g, and nitrilotriacetic acid 38.2 g and the suspension is nitrogen purged for several minutes. The flask is stoppered and the mixture is stirred at room temperature for 3 days. A small amount of unreacted NTA is filtered out. The bulk of the solvent 79 ml is removed in vacuo at a bath temperature of 60°-70° C. The resulting viscous solution is twice roto-vacued after two successive additions of 40 ml dimethylformamide.

Aufarbeitung

  1. custompurged for several minutes
  2. filtrationA small amount of unreacted NTA is filtered out
  3. customThe bulk of the solvent 79 ml is removed in vacuo at a bath temperature of 60°-70° C

Quellen und Nachweise

ORD-Eintrag
ord-d939aa6022c844578f13e673c4c67748
Quelldatensatz
uspto-grants-1984_06
Patentnummer
US04454107

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