Potassium Bromide → 7-Bromo-6-hydroxy-1-heptanol

HRID 1263274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1263274
[O:1]1[CH2:9][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[Br-:10].[K+].C(=O)(O)[O-].[Na+]>C(O)(=O)C.O1CCCC1.CCOCC>[Br:10][CH2:9][CH:2]([OH:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8]

Komponenten

6

Edukt 3

HCID 253877Potassium BromideHCID 516892Sodium BicarbonateHCID 136166735-(Oxiran-2-yl)pentan-1-ol

Produkt 1

HCID 133660747-Bromo-6-hydroxy-1-heptanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 23444217Acetic acid tetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 5 (120 mg, 0.9 mmol) in acetic acid-tetrahydrofuran (2 mL-0.4 mL) was treated with 0.3 mL of saturated aqueous potassium bromide solution at room temperature over 67 hours. It was then diluted with ether and poured into saturated aqueous sodium bicarbonate. The separated organic layer was washed with saturated sodium thiosulfite, saturated sodium chloride, and dried over magnesium sulfate. Evaporation of the solvent gave 127 mg of 7-bromo-6-hydroxy-1-heptanol (4).

Aufarbeitung

  1. washThe separated organic layer was washed with saturated sodium thiosulfite, saturated sodium chloride
  2. dry with materialdried over magnesium sulfate
  3. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-e55ae0ea8bc44e1187f5e1d9052070fc
Quelldatensatz
uspto-grants-1984_06
Patentnummer
US04456613

Notizen zur Reaktion

Wird geladen…