Trifluoroacetic acid → HCID 18614298, Verbindung

HRID 1265154Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1265154
C([O:8][C:9]1[CH:10]=[C:11]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[O:12][C:13]1[C:18]([CH3:19])=[CH:17][C:16]([N+:20]([O-:22])=[O:21])=[CH:15][C:14]=1[CH3:23])C1C=CC=CC=1.C(O)(C(F)(F)F)=O.C1(SC)C=CC=CC=1>>[OH:8][C:9]1[CH:10]=[C:11]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[O:12][C:13]1[C:14]([CH3:23])=[CH:15][C:16]([N+:20]([O-:22])=[O:21])=[CH:17][C:18]=1[CH3:19]

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 18614245HCID 18614245, Verbindung

Produkt 1

HCID 18614298HCID 18614298, VerbindungAusbeute 95,4 %

Versuchsvorschrift

A solution of 4-(3-benzyloxy-4-methoxyphenoxy)-3,5-dimethylnitrobenzene (1.65 g), TFA (3.5 mL) and thioanisole (2.2 mL) were stirred for 4 h. The reaction was partitioned between ethyl acetate and water, the organic layer dried over sodium sulfate and concentrated in vacuo. Flash chromatography afforded 4-(3-hydroxy-4-methoxyphenoxy)-3,5-dimethylnitrobenzene (1.2 g) as a yellow oil.

Aufarbeitung

  1. customThe reaction was partitioned between ethyl acetate and water
  2. dry with materialthe organic layer dried over sodium sulfate
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3e42e0696c714957a2a918848676a086
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06545018B2

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