Sodium Chloride → Moxifloxacin

HRID 1265944Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1265944
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].Cl.[Cl-].[Na+]>O>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20]

Komponenten

4

Edukt 2

HCID 5234Sodium ChlorideHCID 101526Moxifloxacin Hydrochloride

Produkt 1

HCID 152946Moxifloxacin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
121 °C

Versuchsvorschrift

The water is initially charged in a reaction vessel made of glass, and moxifloxacin hydrochloride is dissolved therein with stirring. Sodium chloride is added to the solution of the active compound and dissolved therein. An Fe(III) chloride solution is added to the mixture. The mixture is filtered through a 0.2 μm sterile filter and in each case 250 ml are filled into an infusion bottle which is closed and heated in an autoclave at 121° C. for 20 min.

Aufarbeitung

  1. dissolutionis dissolved
  2. dissolutiondissolved
  3. filtrationThe mixture is filtered through a 0.2 μm
  4. filtrationsterile filter and in each case 250 ml
  5. additionare filled into an infusion bottle which
  6. customis closed

Quellen und Nachweise

ORD-Eintrag
ord-537fac695b5f47cd9788065522379c4b
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06548079B1

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