Sodium Hydroxide → N,N-bis(2,3-epoxypropyl)glycine

HRID 1266Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1266
Cl[CH2:2][CH:3]([OH:15])[CH2:4][N:5]([CH2:10][CH:11]([OH:14])[CH2:12]Cl)[CH2:6][C:7]([OH:9])=[O:8].[Na].[OH-].[Na+]>O>[O:14]1[CH2:12][CH:11]1[CH2:10][N:5]([CH2:4][CH:3]1[O:15][CH2:2]1)[CH2:6][C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86752178sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine

Produkt 1

HCID 19695060N,N-bis(2,3-epoxypropyl)glycineAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A reactor was charged with 20 g (0.07 mole) of sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine obtained in the same manner as in Referential Example 1 and 100 g of water, and the contents were kept at 50° C., to which 35 ml of a 4N aqueous solution of sodium hydroxide were added. After the mixture was stirred for 30 minutes, the solvent was distilled off under reduced pressure, and 100 ml of ethanol were added to the residue to separate insoluble matter by filtration. Thereafter, ethanol was distilled off under reduced pressure, thereby obtaining 11 g (isolation yield: 84%) of N,N-bis(2,3-epoxypropyl)glycine.

Aufarbeitung

  1. additionwere added
  2. distillationthe solvent was distilled off under reduced pressure, and 100 ml of ethanol
  3. additionwere added to the residue
  4. customto separate insoluble matter
  5. filtrationby filtration
  6. distillationThereafter, ethanol was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f88ac48b7e45476aa2b72c1493bc7762
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723655

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