p-Toluenesulfonic acid → 2-Methyl-3H-cyclopenta[a]naphthalene
Reaktionsgleichung
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4](S(O)(=O)=O)=[CH:3][CH:2]=1>O>[CH3:4][C:5]1[CH2:6][C:2]2[CH:3]=[CH:4][C:5]3[CH:3]=[CH:2][CH:1]=[CH:11][C:6]=3[C:1]=2[CH:11]=1Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
p-Toluenesulfonic acid (50 mg) was added to the organic layer, and the reaction mixture was heated under reflux with water separation for 1 h. After cooling to room temperature the organic layer was washed with sodium bicarbonate (aqueous 2 wt %, 50 ml), dried over magnesium sulfate, and concentrated under reduced pressure. The yield of 2-methyl-3H-benz[e]indene was 4.1 g or 89%.
Aufarbeitung
- temperaturethe reaction mixture was heated
- washwas washed with sodium bicarbonate (aqueous 2 wt %, 50 ml)
- dry with materialdried over magnesium sulfate
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-19aaf8e486644df6b67ee861747a8325
- Quelldatensatz
- uspto-grants-2003_04
- Patentnummer
- US06548710B2
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