Dimethylformamide → HCID 18544790, Verbindung

HRID 1266924

Reaktionsgleichung

Reaktionsgleichung von HRID 1266924
[F:1][C:2]([F:14])([C:5]([F:13])([F:12])[C:6]([F:11])([F:10])[CH:7]([F:9])[F:8])[CH2:3][OH:4].CN(C=O)C.C(=O)([O-])[O-].[K+].[K+].[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29](F)[N:28]=1>O>[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([O:4][CH2:3][C:2]([F:14])([F:1])[C:5]([F:12])([F:13])[C:6]([F:10])([F:11])[CH:7]([F:8])[F:9])[N:28]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 96412,2,3,3,4,4,5,5-Octafluoro-1-pentanolHCID 11430Potassium CarbonateHCID 739342,6-Difluoropyridine

Produkt 1

HCID 18544790HCID 18544790, VerbindungAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A reaction flask was loaded with 2,2,3,3,4,4,5,5-octafluoropentanol (16.1 g), DMF (42 ml), anhydrous potassium carbonate (9.6 g), followed by stirring at room temperature for one hour. To this mixture, 2,6-difluoropyridine (8.0 g) was dropwise added. The temperature was raised to 60° C., and the mixture was stirred for four hours. The heating was stopped, and water was added to the reaction mixture, followed by extraction with ethyl acetate. The extract was condensed by an evaporator to give 2-fluoro-6-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-pyridine (20 g).

Aufarbeitung

  1. temperatureThe temperature was raised to 60° C.
  2. stirringthe mixture was stirred for four hours
  3. extractionfollowed by extraction with ethyl acetate
  4. customcondensed
  5. customby an evaporator

Quellen und Nachweise

ORD-Eintrag
ord-330d9699c2c744848e0eb9f9573a1571
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06551682B1

Verknüpfte Notizen

Wird geladen…