1,2-Naphthoquinone → HCID 135754684, Verbindung

HRID 1266929Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1266929
[C:1]1(=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]1=O.[NH:13]([C:15]1[C:20]([C:21]([F:24])([F:23])[F:22])=[C:19]([O:25][CH3:26])[N:18]=[C:17]([CH3:27])[N:16]=1)[NH2:14]>C(O)(=O)C>[CH3:26][O:25][C:19]1[N:18]=[C:17]([CH3:27])[N:16]=[C:15]([N:13]=[N:14][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:1]=2[OH:12])[C:20]=1[C:21]([F:24])([F:23])[F:22]

Komponenten

4

Edukt 2

HCID 106671,2-Naphthoquinone2×HCID 18544800HCID 18544800, Verbindung

Produkt 1

HCID 135754684HCID 135754684, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

Then, a flask was loaded with acetic acid (50 ml) and 1,2-naphthoquinone (2.9 g), and the temperature was raised up to 110° C. with stirring to dissolve 1,2-naphthoquinone. To this mixture, 4-hydrazino-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine (4 g) was added in 30 minutes. After stirring at 110° C. for 3 hours, the heating was stopped and left to cool. The reaction mixture was filtrated. The filtrated crystals were recrystallized with dioxane to give crystals, which were then filtrated and dried to give intended crystals (2.3 g).

Aufarbeitung

  1. stirringAfter stirring at 110° C. for 3 hours
  2. waitleft
  3. temperatureto cool
  4. filtrationThe reaction mixture was filtrated
  5. customThe filtrated crystals were recrystallized with dioxane
  6. customto give crystals, which
  7. filtrationwere then filtrated
  8. customdried
  9. customto give

Quellen und Nachweise

ORD-Eintrag
ord-f9b3d5abc5944628b853fa1d429791b3
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06551682B1

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