Ethanol → 2-Amino-3-methoxypyridine
Reaktionsgleichung
[CH3:1][O:2][C:3]1[C:4]([N+:9]([O-])=O)=[N:5][CH:6]=[CH:7][CH:8]=1.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[SH-].C(O)C>O.C1(C)C=CC=CC=1>[NH2:9][C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][N:5]=1Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
Then, a reaction flask was loaded with this 3-methoxy-2-nitropyridine (9.0 g), sodium sulfide enneahydrate (64 g), ethanol (93 ml) and water (46 ml) and they were mixed, followed by stirring at 70° C. for 2.5 hours. Then, the mixture was cooled to room temperature. To this, toluene and water were added, followed by stirring. The organic layer was collected and washed with a saline solution, and then dried with sodium sulfate. This was filtrated and the filtrate was condensed to give 2-amino-3-methoxypyridine (5.1 g).
Aufarbeitung
- additionwere mixed
- temperatureThen, the mixture was cooled to room temperature
- stirringby stirring
- customThe organic layer was collected
- washwashed with a saline solution
- dry with materialdried with sodium sulfate
- filtrationThis was filtrated
- customcondensed
Quellen und Nachweise
- ORD-Eintrag
- ord-5ffa6e064cb244a3a4d125a5a4d4c577
- Quelldatensatz
- uspto-grants-2003_04
- Patentnummer
- US06551682B1
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