Imidazole → HCID 12786233, Verbindung

HRID 126728Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 126728
[OH:1][C:2]([CH3:10])([CH2:6][CH2:7][CH:8]=[CH2:9])[CH2:3][C:4]#[CH:5].N1C=CN=C1.CN(C)C=O.[CH3:21][Si:22]([CH3:26])([CH3:25])OCl>O>[CH3:10][C:2]([O:1][Si:22]([CH3:26])([CH3:25])[CH3:21])([CH2:6][CH2:7][CH:8]=[CH2:9])[CH2:3][C:4]#[CH:5]

Komponenten

6

Edukt 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 205650044-Hydroxy-4-methyl-oct-1-yn-7-eneHCID 20565034HCID 20565034, Verbindung

Produkt 1

HCID 12786233HCID 12786233, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of 50 g. of 4-hydroxy-4-methyl-oct-1-yn-7-ene and 61.3 g. of imidazole in 100 ml. of dimethylformamide at 0° C., is added, with stirring, 49.1 g. of trimethylsilyloxy chloride. The mixture is stirred at room temperature overnight and poured into petroleum ether and water. The organic layer is washed with water and saturated sodium bicarbonate solution and dried over magnesium sulfate. The solvent is removed and the residue distilled (74°-78° C., 1.5 mm.) to give the product as a colorless liquid.

Aufarbeitung

  1. additionTo a mixture of 50 g
  2. stirringThe mixture is stirred at room temperature overnight
  3. washThe organic layer is washed with water and saturated sodium bicarbonate solution
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed
  6. distillationthe residue distilled (74°-78° C., 1.5 mm.)

Quellen und Nachweise

ORD-Eintrag
ord-263bc6dc480d406c951e2042df817117
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04254036

Notizen zur Reaktion

Wird geladen…