Acetic Anhydride → Ethyl 1-acetyl-4-piperidineacetate

HRID 126856

Reaktionsgleichung

Reaktionsgleichung von HRID 126856
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1>CC1C=CC=CC=1>[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 2760465Ethyl 2-(piperidin-4-yl)acetate

Produkt 1

HCID 54363171Ethyl 1-acetyl-4-piperidineacetateAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 200 parts of acetic acid anhydride, 90 parts of ethyl 4-piperidineacetate and 225 parts of methylbenzene is stirred and refluxed for 3 hours. The reaction mixture is evaporated and the residue is diluted with water. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 92 parts (82%) of ethyl 1-acetyl-4-piperidineacetate as a residue.

Aufarbeitung

  1. temperaturerefluxed for 3 hours
  2. customThe reaction mixture is evaporated
  3. additionthe residue is diluted with water
  4. extractionThe product is extracted with methylbenzene
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3738f18a6d774f939670885c325dad30
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04254127

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