4-Bromophenylhydrazine hydrochloride → N-(6-bromo-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

HRID 126887

Reaktionsgleichung

Reaktionsgleichung von HRID 126887
O=[C:2]1[CH2:7][CH2:6][CH2:5][CH:4]([NH:8][C:9](=[O:11])[CH3:10])[CH2:3]1.Cl.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20]N)=[CH:16][CH:15]=1>CC(O)=O>[Br:13][C:14]1[CH:15]=[C:16]2[C:17](=[CH:18][CH:19]=1)[NH:20][C:2]1[CH2:3][CH:4]([NH:8][C:9](=[O:11])[CH3:10])[CH2:5][CH2:6][C:7]2=1

Komponenten

4

Edukt 2

HCID 121574-Bromophenylhydrazine hydrochlorideHCID 20529251N-(3-oxocyclohexyl)acetamide

Produkt 1

HCID 20529232N-(6-bromo-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A solution of 0.05 mol of N-(3-oxocyclohexyl) acetamide in 100 ml of glacial HOAc was stirred and heated at 80° C. while adding during 15-30 minutes a warm solution of 0.05 mol of 4-bromophenylhydrazine hydrochloride in 300 ml of glacial HOAc. After an additional 3 hr at 85°, most of the HOAc was evaporated. The residue was triturated with H2O, until solid, the resulting solid was filtered, and recrystallized from ethanol to give the title compound, mp 210°-211°.

Aufarbeitung

  1. custommost of the HOAc was evaporated
  2. customThe residue was triturated with H2O, until solid
  3. filtrationthe resulting solid was filtered
  4. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-9133e6c469124946afc7198e81245021
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04254134

Verknüpfte Notizen

Wird geladen…