Ethanol → HCID 86592347, Verbindung

HRID 1269577Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1269577
[C:1]([O:4][O:5][C:6]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)=[C:8]([Br:23])[C:7]=1[CH2:24][CH3:25])(=[O:3])[CH3:2].C(O)C>C(OC(=O)C)C.Cl[Zn]Cl>[C:1]([O:4][O:5][C:6]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)=[C:8]([Br:23])[C:7]=1[CH2:24][CH3:25])(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 702EthanolHCID 86592346HCID 86592346, Verbindung

Produkt 1

HCID 86592347HCID 86592347, VerbindungAusbeute 88,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 5727Zinc ChlorideKatalysatorHCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

Ethyl(3,5-dibromo-4-[4-nitrophenoxy]phenoxy) acetate (2.4 g), zink chloride (5.7 g), ethylacetate (30 mL) and ethanol (30 mL) was heated at reflux for two hours. After cooling down to room temperature, the reaction mixture was diluted with ethylacetate, washed with a saturated aqueous solution of sodium hydrogencarbonate and the organic phase dried over potassium carbonate. After concentration, 2.0 g of ethyl(3,5-dibromo-4-[4-aminophenoxy]phenoxy) acetate was obtained as a brown oil.

Aufarbeitung

  1. temperatureat reflux for two hours
  2. washwashed with a saturated aqueous solution of sodium hydrogencarbonate
  3. dry with materialthe organic phase dried over potassium carbonate
  4. concentrationAfter concentration

Quellen und Nachweise

ORD-Eintrag
ord-22611691b7884236bb529b6a2835dc8c
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07199265B2

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