Methanol → 4-(4-Chlorophenyl)-2-(methylsulfonyl)pyrimidine

HRID 1269626Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1269626
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](SC)[N:9]=2)=[CH:4][CH:3]=1.O[O:17][S:18]([O-:20])=O.[K+].[CH3:22]O>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([S:18]([CH3:22])(=[O:20])=[O:17])[N:9]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 28211934-(4-Chlorophenyl)-2-(methylthio)pyrimidineHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 219059934-(4-Chlorophenyl)-2-(methylsulfonyl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A solution of 4-(4-chlorophenyl)-2-(methylthio)pyrimidine (3 g, 12.71 mmol), in methanol (125 mL) and water (125 mL) under nitrogen at 4° C. was treated with oxone™ (23.44 g, 38.13 mmol), stirred and allowed to warm up to room temperature for 18 h. The reaction mixture was diluted with water (220 mL), extracted with CHCl3 (250 mL), dried (Na2SO4) and the solvent removed in vacuo to afford the title compound as a yellow solid (3.36 g).

Aufarbeitung

  1. extractionextracted with CHCl3 (250 mL)
  2. dry with materialdried (Na2SO4)
  3. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0e09b4b7d1204ed2a586831daeaeb313
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07199239B2

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