Ammonia → 2-Bromo-6-(4-methylphenyl)pyrazine

HRID 1269635Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1269635
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:3]=1.P(Br)(Br)[Br:16].N>O>[Br:16][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 24614Phosphorus tribromideHCID 184483262-Chloro-6-(4-methylphenyl)pyrazine

Produkt 1

HCID 184483232-Bromo-6-(4-methylphenyl)pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a flask containing 2-chloro-6-(4-methylphenyl)pyrazine (2.5 g, 12.3 mmol), was added phosphorus tribromide (20 mL) and the mixture heated at reflux for 6 h under nitrogen. The reaction mixture was cooled to room temperature prior to pouring carefully into iced water (600 mL). The resulting solution was adjusted to pH 6–7 using aqueous ammonia and extracted with Et2O (2×250 mL). The organic solution was dried (MgSO4) and the solvent removed in vacuo to afford the title compound as a white solid (2.32 g).

Aufarbeitung

  1. temperaturethe mixture heated
  2. temperatureat reflux for 6 h under nitrogen
  3. extractionextracted with Et2O (2×250 mL)
  4. dry with materialThe organic solution was dried (MgSO4)
  5. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-27f4149e1e044c8ebf87231a73f422a9
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07199239B2

Notizen zur Reaktion

Wird geladen…