Acetic Anhydride → N-(4-cyano-2,3-dimethylphenyl)acetamide

HRID 1269863Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1269863
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[C:11]([CH3:17])[C:10]=1[CH3:18]>C(OCC)(=O)C>[C:13]([C:12]1[CH:15]=[CH:16][C:9]([NH:8][C:5](=[O:7])[CH3:6])=[C:10]([CH3:18])[C:11]=1[CH3:17])#[N:14]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 199903354-Amino-2,3-dimethylbenzonitrile

Produkt 1

HCID 22934081N-(4-cyano-2,3-dimethylphenyl)acetamideAusbeute 81,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Acetic anhydride (1.36 ml, 14.4 mmol) was added to a solution of 4-amino-2,3-dimethylbenzonitrile (1.32 g, 9.03 mmol) in ethyl acetate (10 ml) at room temperature, and then the reaction was carried out for 4 hours under reflux conditions. After the reaction mixture was cooled, the precipitate obtained was collected by filtration and dried to obtain N-(4-cyano-2,3-dimethylphenyl)acetamide (1.39 g, 81.8%).

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled
  2. customthe precipitate obtained
  3. filtrationwas collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a84cea353cc84605af45e385dc594a57
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07199147B2

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