Sulfuric Acid → HCID 86737540, Verbindung

HRID 126995Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 126995
[CH2:1]([O:8][C:9]([N:11]1[CH:15]([C:16]([OH:18])=[O:17])[CH2:14][C:13]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][C:25](=[CH2:27])[CH3:26].S(=O)(=O)(O)O>CCOCC>[CH2:1]([O:8][C:9]([N:11]1[CH:15]([C:16]([O:18][C:25]([CH3:27])([CH3:26])[CH3:24])=[O:17])[CH2:14][C:13]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 20288724(+/-)-4,5-Dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid

Produkt 1

HCID 86737540HCID 86737540, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 6.6 g of (±)-4,5-dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, 5 ml of isobutylene, 25 ml of ether and 0.25 ml of concentrated sulfuric acid is shaken in a pressure vessel for about 16 hours. The reaction vessel is vented (-10° C.) and the contents are washed with ice cold aqueous sodium hydroxide. The organic fraction is dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title compound.

Aufarbeitung

  1. custom(-10° C.)
  2. washthe contents are washed with ice cold aqueous sodium hydroxide
  3. dry with materialThe organic fraction is dried over anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6b242c2ec9d541f9baf79fab80cb00b6
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04254267

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