Triethylamine → 40316-56-1

HRID 1270053Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1270053
[C:1]1([C:7]#[C:8]/[CH:9]=[CH:10]/[CH2:11]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.CS([Cl:24])(=O)=O>ClCCl>[Cl:24][CH2:11]/[CH:10]=[CH:9]/[C:8]#[C:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 546319840317-08-6

Produkt 1

HCID 546319740316-56-1Ausbeute 82,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a mixture of (E)-5-phenyl-pent-2-en-4-yn-1-ol (Method 1b) (4.9 g, 31.0 mmol) and triethylamine (3.8 g, 38.0 mmol) in dry dichloromethane (200 mL) was added methanesulfonyl chloride (3.8 g, 33 mmol) dropwise. Stirring was continued at room temperature overnight. The reaction mixture was concentrated in vacuo and the residue washed with heptane/dichloromethane (×2) to give 4.5 g (82%) crude (E)-(5-chloro-pent-3-en-1-ynyl)-benzene.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. washthe residue washed with heptane/dichloromethane (×2)

Quellen und Nachweise

ORD-Eintrag
ord-e6b9acc0a27c4c0bb64667f7c3c712e3
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07202213B2

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