Potassium Iodide → HCID 86583975, Verbindung

HRID 1270054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1270054
Cl[CH2:2]/[CH:3]=[CH:4]/[C:5]#[C:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH2:13]([O:15][C:16](=[O:29])[C@@H:17]([O:26][CH2:27][CH3:28])[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1)[CH3:14].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O.O>[CH2:13]([O:15][C:16](=[O:29])[C@@H:17]([O:26][CH2:27][CH3:28])[CH2:18][C:19]1[CH:20]=[CH:21][C:22]([O:25][CH2:2]/[CH:3]=[CH:4]/[C:5]#[C:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:23][CH:24]=1)[CH3:14]

Komponenten

7

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 546319740316-56-1HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

Produkt 1

HCID 86583975HCID 86583975, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of (E)-(5-chloro-pent-3-en-1-ynyl)-benzene (177 mg, 1.0 mmol) and (S)-2-ethoxy-3-(4-hydroxy-phenyl)-propionic acid ethyl ester (238 mg, 1.0 mmol) in acetone (15 mL) was added potassium carbonate (700 mg, 5.0 mmol) and potassium iodide (17 mg, 0.1 mmol). The mixture was heated to reflux over night with stirring. Water was added and the product extracted with tert-butyl methyl ether (×3) The combined organic phases were dried (MgSO4), filtered and concentrated in vacuo, to give the title compound as a crude product.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux over night
  3. extractionthe product extracted with tert-butyl methyl ether (×3) The combined organic phases
  4. dry with materialwere dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d796ea704a19466483e27b0f5290b75b
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07202213B2

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