4-Amino-7-[3,5-bis-o-(2,4-dichlorophenylmethyl)-2-c-hydroxymethyl-beta-d-ribofuranosyl]-7h-pyrrolo[2,3-d]pyrimidine → 4-Amino-7-(2-C-hydroxymethyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

The compound from Step B (120 mg, 0.2 mmol) was dissolved in 1:1 methanol/dichloromethane, 10% Pd—C was added, and the suspension stirred under an H2 atmosphere for 12 h. The catalyst was removed by filtration through a celite pad and washed with copious amounts of methanol. The combined filtrate was evaporated in vacuo and the residue was purified by flash chromatography (SiO2, 10% methanol in EtOAc containing 0.1% triethylamine) to give the title compound (50 mg) as a white powder.