Reaktionsgleichung
[OH-].[K+].[CH3:3][S:4]([NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=1)(=[O:6])=[O:5].C(OCC)(=O)C>O>[CH3:3][S:4]([NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=1)(=[O:5])=[O:6]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of potassium hydroxide (2.9 g.) in water (80 ml.) was added ethyl 2-methanesulfonamidothiazol-4-ylacetate (9.1 g.) under ice-cooling and stirring, and the mixture was stirred for 1 hour at room temperature. After the reaction, to the reaction mixture was added a mixture of water and ethyl acetate, and then the aqueous layer was separated. The remaining ethyl acetate layer was extracted twice with 10% hydroxide aqueous solution. The extracts were combined with the above obtained aqueous layer, and the mixture was acidified with hydrochloric acid under ice-cooling. The precipitated crystals were collected by filtration, washed with water and dried to give 2-methanesulfonamidothiazol-4-ylacetic acid (5.94 g.), mp 158°-160° C. (dec.).
Aufarbeitung
- temperaturecooling
- stirringthe mixture was stirred for 1 hour at room temperature
- customAfter the reaction
- additionto the reaction mixture was added
- customthe aqueous layer was separated
- extractionThe remaining ethyl acetate layer was extracted twice with 10% hydroxide aqueous solution
- temperaturecooling
- filtrationThe precipitated crystals were collected by filtration
- washwashed with water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-b087c7777af54fa09f7e39a51b4c0f64
- Quelldatensatz
- uspto-grants-1981_03
- Patentnummer
- US04254260
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