Hydrochloric Acid → 2-acetamido-5-[N-(1-ethylpropyl)aminosulfonyl]-1,3,4-thiadiazole

HRID 127138

Reaktionsgleichung

Reaktionsgleichung von HRID 127138
[CH2:1]([CH:3]([NH2:6])[CH2:4][CH3:5])[CH3:2].[C:7]([NH:10][C:11]1[S:12][C:13]([S:16](Cl)(=[O:18])=[O:17])=[N:14][N:15]=1)(=[O:9])[CH3:8].Cl>O>[C:7]([NH:10][C:11]1[S:12][C:13]([S:16]([NH:6][CH:3]([CH2:4][CH3:5])[CH2:1][CH3:2])(=[O:17])=[O:18])=[N:14][N:15]=1)(=[O:9])[CH3:8]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 120193-PentanamineHCID 128944515-(Acetylamino)-1,3,4-thiadiazole-2-sulfonyl chloride

Produkt 1

HCID 202860992-acetamido-5-[N-(1-ethylpropyl)aminosulfonyl]-1,3,4-thiadiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

1-Ethylpropylamine (0.1 mole) and water (50 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer. The solution is cooled to 20° C. and stirred while 2-acetamido-5-chlorosulfonyl-1,3,4-thiadiazole (0.1 mole) is added slowly while holding the reaction temperature between 0° C. and 20° C. At the conclusion of the addition, stirring is continued for a period of about 2 hours at room temperature. The reaction mixture is then neutralized with 6 N hydrochloric acid. Solids are filtered out, water washed and dried to yield the desired product 2-acetamido-5-[N-(1-ethylpropyl)aminosulfonyl]-1,3,4-thiadiazole.

Aufarbeitung

  1. customfitted with a mechanical stirrer
  2. additionis added slowly
  3. customthe reaction temperature between 0° C. and 20° C
  4. additionAt the conclusion of the addition
  5. filtrationSolids are filtered out
  6. washwater washed
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c43c42815bbb46be9f7e18a75cdefbf4
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04255182

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