2-Amino-4-fluorophenol → 5-Fluoro-2(3H)-benzoxazolone

HRID 1271682

Reaktionsgleichung

Reaktionsgleichung von HRID 1271682
[C:1](C1NC=CN=1)(C1NC=CN=1)=[O:2].[NH2:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[OH:21]>ClCCl>[F:20][C:18]1[CH:17]=[CH:16][C:15]2[O:21][C:1](=[O:2])[NH:13][C:14]=2[CH:19]=1

Komponenten

4

Edukt 2

HCID 27359172-Amino-4-fluorophenolHCID 5250894Bis-(1H-imidazol-2-YL)-methanone

Produkt 1

HCID 2872085-Fluoro-2(3H)-benzoxazoloneAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Carbonyl diimidazole (7.6 g) was added to a solution of 2-amino-4-fluorophenol (5 g, 39 mmol) in dichloromethane (0.100 ml). After 14 hours the solution was washed with 5M aqueous HCl, water, and dried over magnesium sulfate. The solution was filtered through a plug of silica and evaporated affording a white solid (4.0 g, 66%).

Aufarbeitung

  1. washAfter 14 hours the solution was washed with 5M aqueous HCl, water
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe solution was filtered through a plug of silica
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-4546198c3ac949d9ac091528485bf21a
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07205408B2

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