2-Amino-4-fluorophenol → 5-Fluoro-2(3H)-benzoxazolone

Beteiligte Stoffe

Reaktionsschritte

Carbonyl diimidazole (7.6 g) was added to a solution of 2-amino-4-fluorophenol (5 g, 39 mmol) in dichloromethane (0.100 ml). After 14 hours the solution was washed with 5M aqueous HCl, water, and dried over magnesium sulfate. The solution was filtered through a plug of silica and evaporated affording a white solid (4.0 g, 66%).

Herkunft & Nachweise