Hydroxyamine hydrochloride → 4-Fluoro-2-(5-isoxazolyl)phenol
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]=[CH:6][C:5]2=[O:12].Cl.[NH2:14]O>C(O)C>[F:1][C:2]1[CH:11]=[CH:10][C:9]([OH:8])=[C:4]([C:5]2[O:12][N:14]=[CH:7][CH:6]=2)[CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The product from above (6-fluorochromen-4-one (5.25 g, 32.0 mmol) and hydroxylamine hydrochloride (4.65 g, 67.2 mmol) are dissolved in ethanol (180 ml) and the resulting mixture is heated to reflux. The reaction is allowed to stir for 18 hours before cooling and concentrating. The residue is taken up in toluene and filtered to give 690 mg of 4-fluoro-2-isoxazol-5-yl-phenol and from the filtrate 594 mg of 4-fluoro-2-isoxazol-3-yl-phenol.
Aufarbeitung
- temperaturethe resulting mixture is heated to reflux
- temperaturebefore cooling
- concentrationconcentrating
- filtrationfiltered
Quellen und Nachweise
- ORD-Eintrag
- ord-4ac770502896430e878b8a40f36d127a
- Quelldatensatz
- uspto-grants-2007_04
- Patentnummer
- US07208505B2
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