4-Aminopyridine → 3-Methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione

HRID 127285

Reaktionsgleichung

Reaktionsgleichung von HRID 127285
[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])O[C:3]1=[O:4].[NH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1.C1(C)C(C)=CC=CC=1>O>[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])[N:9]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[C:3]1=[O:4]

Komponenten

5

Edukt 3

HCID 17274-AminopyridineHCID 7237O-XyleneHCID 20051Methylsuccinic anhydride

Produkt 1

HCID 128225463-Methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The starting material is prepared as follows: The mixture of 28.5 g of 2-methylsuccinic anhydride, 23.5 g of 4-aminopyridine and 350 ml of xylene is refluxed on a water separator while stirring for 3.5 hours. The hot solution is decanted from some gummy residue, cooled, filtered, the residue suspended in 100 ml of boiling isopropanol and filtered off again, to yield the 3-methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 119°-120°.

Aufarbeitung

  1. customThe starting material is prepared
  2. customThe hot solution is decanted from some gummy residue
  3. temperaturecooled
  4. filtrationfiltered
  5. filtrationfiltered off again

Quellen und Nachweise

ORD-Eintrag
ord-934277f0ce874393a387b4c7de63e85d
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04255429

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