4-Aminopyridine → 4-Phenyl-1-(4-pyridyl)-piperidin-2,6-dione

HRID 127286Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 127286
[C:1]1([CH:7]2[CH2:13][C:12](=[O:14])[O:11][C:9](=O)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1.C1(C)C(C)=CC=CC=1.CS(O)(=O)=O>O>[C:1]1([CH:7]2[CH2:8][C:9](=[O:11])[N:15]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[C:12](=[O:14])[CH2:13]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

6

Edukt 4

HCID 17274-AminopyridineHCID 6395Methanesulfonic AcidHCID 7237O-XyleneHCID 2978824-Phenyloxane-2,6-dione

Produkt 1

HCID 128225504-Phenyl-1-(4-pyridyl)-piperidin-2,6-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The starting material is prepared as follows: The mixture of 19 g of 3-phenylglutaric anhydride, 10.3 g of 4-aminopyridine, 350 ml of xylene and 2.5 g of methane sulfonic acid is refluxed on a water separator while stirring for 2 days. The hot solution is decanted from some insolubles, cooled, filtered an the residue triturated with hot isopropanol, to yield the 4-phenyl-1-(4-pyridyl)-piperidin-2,6-dione meling at 229°-230°; the analogously prepared 4-(p-methoxyphenyl)-1-(4-pyridyl)-piperidine-2,6-dione melts at 168°-169°.

Aufarbeitung

  1. customThe starting material is prepared
  2. customThe hot solution is decanted from some insolubles
  3. temperaturecooled
  4. filtrationfiltered an the residue
  5. customtriturated with hot isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-144958cd5ae748fa9675cbce395c87c3
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04255429

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