Iodoethane → 1-Chloro-4-ethoxy-2-nitrobenzene

HRID 1274365

Reaktionsgleichung

Reaktionsgleichung von HRID 1274365
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12](I)[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)[CH3:13]

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 691274-Chloro-3-nitrophenol

Produkt 1

HCID 2407341-Chloro-4-ethoxy-2-nitrobenzeneAusbeute 97,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 4-chloro-3-nitrophenol (5.00 g, 29 mmol) in acetone (50 ml) were added ethyl iodide (4.95 g, 32 mmol) and potassium carbonate (4.37 g, 32 mmol), followed by stirring at room temperature for 20 hours. After filtration of the insoluble matter, the filtrate was subjected to evaporation under reduced pressure to remove the solvent, and the residue was purified by silica gel column chromatography (eluent; chloroform) to give 4-ethoxy-1-chloro-2-nitrobenzene (5.71 g).

Aufarbeitung

  1. filtrationAfter filtration of the insoluble matter
  2. customthe filtrate was subjected to evaporation under reduced pressure
  3. customto remove the solvent
  4. customthe residue was purified by silica gel column chromatography (eluent; chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-46792c3674284c289776725f648199e7
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06156801

Verknüpfte Notizen

Wird geladen…