Reaktionsgleichung
Cl.[CH3:2][NH:3][CH3:4].[CH2:5]=O.[CH2:7]([N:14]1[CH:18]=[CH:17][CH:16]=[CH:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>>[CH3:2][N:3]([CH2:5][C:15]1[N:14]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:18]=[CH:17][CH:16]=1)[CH3:4]Komponenten
5
Versuchsvorschrift
A solution of 8.2 g. (0.1 mole) dimethylamine hydrochloride in 8 ml. formalin is added dropwise to 17.12 g. (0.1 mole) of 1-benzylpyrrole. The mixture is stirred at room temperature until solution occurs (about 4 hours). The solution is poured into 10% sodium hydroxide solution and then extracted into ether three times. The combined organic fractions are washed with a saturated solution of sodium chloride, dried over magnesium sulfate and the solvent evaporated in vacuo. The product, 2-dimethylaminomethyl-1-benzylpyrrole, is distilled at reduced pressure, b.p. 73° C., 0.025 mm. Hg.
Aufarbeitung
- custom(about 4 hours)
- extractionextracted into ether three times
- washThe combined organic fractions are washed with a saturated solution of sodium chloride
- dry with materialdried over magnesium sulfate
- customthe solvent evaporated in vacuo
- distillationThe product, 2-dimethylaminomethyl-1-benzylpyrrole, is distilled at reduced pressure, b.p. 73° C., 0.025 mm. Hg
Quellen und Nachweise
- ORD-Eintrag
- ord-2fde69fa16784a4a9340a7789f91fca6
- Quelldatensatz
- uspto-grants-2000_12
- Patentnummer
- US06160003
Verknüpfte Notizen
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