Hydrochloric Acid → HCID 22117884, Verbindung

HRID 1275804

Reaktionsgleichung

Reaktionsgleichung von HRID 1275804
[NH2:1][C:2]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH:10](OC)(OC)OC.[ClH:17]>CC(C)=O>[ClH:17].[N:1]1[C:2]2([CH2:6][CH2:5][CH2:4][CH2:3]2)[C:7](=[O:8])[NH:9][CH:10]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 9005Trimethyl orthoformateHCID 111160861-Aminocyclopentanecarboxamide

Produkt 1

HCID 22117884HCID 22117884, VerbindungAusbeute 92,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

20 g (0.156 mol) of 1-aminocyclopentane-1-carboxamide and 28 g (0.19 mol) of trimethyl orthoformate are refluxed for 1 hour. The condenser is then changed to a "No hold up" condenser, and the temperature is elevated to 140° C. inner temperature. The residue is dissolved in 150 ml of acetone the pH is adjusted to 1-2 with concentrated hydrochloric acid and after cooling the resulting suspension the product is filtered of. 25 g of the title compound is obtained, yield 92.2%.

Aufarbeitung

  1. customis elevated to 140° C.
  2. temperatureafter cooling the resulting suspension the product
  3. filtrationis filtered of

Quellen und Nachweise

ORD-Eintrag
ord-5da5585de34e472e8f5e69bf89eaff3a
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06162923

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