Hydrazine hydrate (1:1) → 5-Bromo-1-naphthohydrazide

HRID 1276286

Reaktionsgleichung

Reaktionsgleichung von HRID 1276286
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([O:14]C)=O.O.[NH2:17][NH2:18]>CO>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([NH:17][NH2:18])=[O:14]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 4557673Methyl 5-bromo-1-naphthoate

Produkt 1

HCID 221158865-Bromo-1-naphthohydrazideAusbeute 65,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 5-bromo-1-naphthoate (D1) (5.32 g, 20 mmol) and hydrazine hydrate (5.7 ml, 100 mmol) were stirred at reflux in methanol (50 ml) for 48 h. After cooling, the solid was filtered off, washed with cold methanol, and dried in vacuo at 60° C., yielding the title compound (3.48 g, 65%) as a grey-brown crystalline powder.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. washwashed with cold methanol
  4. customdried in vacuo at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-df9142386daf43d2804491a3bbe60fda
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06166034

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